Keibler was a contestant on the second season of Dancing with the Stars, where she placed third.She has also appeared on other American Broadcasting Company (ABC) shows such as What About Brian, George Lopez, and October Road, as well as the 100th episode of the CBS sitcom How I Met Your Mother as a bartender and on the USA Network show Psych. In addition, she has modeled appearing in both Maxim and Stuff magazines.
After attending The Catholic High School of Baltimore, she attended Towson University, where she studied mass communication. She attended the university on a partial-scholarship and had a 3.7 grade point average (GPA). She had minor parts in movies such as Pecker and Liberty Heights, as well as small modeling jobs.During this time, Keibler became a cheerleader for the Baltimore Ravens football team at the age of eighteen.
She competed in the second season of Dancing with the Stars, alongside her dance partner, Tony Dovolani. Keibler received a perfect score of 30 from the three judges for her samba dance routine in week five. This prompted judge Bruno Tonioli to nickname her a "weapon of mass seduction." Overall, Keibler and Dovolani received four perfect scores. Keibler was eliminated in the final episode, coming in third to Jerry Rice, who placed second in the final round of the competition, and Drew Lachey, the winner of the season. Two of the judges, Bruno Tonioli and Len Goodman, felt she should have at least placed second
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Keibler has appeared on MTV's Punk'd twice. In season five, Keibler took part in helping prank fellow WWE Superstar Triple H, which also included Stephanie McMahon. In season seven, however, Keibler was seen as a victim of a prank by her boyfriend, Geoff Stults.
In February 2007, Keibler began a recurring role in ABC's What About Brian. She played the role of Brian's new neighbor and love interest. This was Keibler's first major acting role, following her previous minor roles in both Bubble Boy and Pecker. Keibler guest starred on The George Lopez Show on ABC. In the fall of 2007, Keibler appeared in both The Comebacks and on ABC's drama October Road.